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Additional resources for Cisco - Introduction to Capacity & Performance Management 609
10. The general structure of a gene. Genes are composed of exons and introns as well as flanking regions. Initially, all exons and introns are transcribed. Subsequent processing in the nucleus splices out the introns and leaves the mature mRNA, which is then transported to the ribosomes located in the cytoplasm. Flanking regions contain nucleotide sequences which regulate gene transcription. Typically, the 5' flanking region (left) contains the promoter, which binds RNA polymerase near the nucleotide sequence known as the "TATA" box and instructs the enzyme to begin transcription I immediately 3' (right).
Cellular and molecular biology have added a substantial increment of information to our knowledge of these processes, and now are increasingly being applied to the heart. Our goal in this next section is to review these phenomena with a view toward the inclusion of newer information. Determinants of Striated Muscle Cell Differentiation The heart, just like skeletal muscle, is derived from the embryonic mesoderm and develops substantially in con- Joel Kupfer and Stanley A. Rubin cert with, and perhaps on signals from, the splanchnic mesoderm.
Tional regulatory factors or cis-acting elements have clearly been identified to account for this behavior. Myosin Gene Expression in Humans: Important Distinctions The discovery of MHC isoforms and their biochemical and physiological implications lead almost immediately to an analysis of human cardiac tissue. The results were somewhat of a surprise and a disappointment. The developmental regulation of MHC in human hearts is similar to that of small animals where alpha MHC is predominant. However, this effect is short-lived in the ventricles, where beta MHC and V3 myosin are vastly predominant throughout the remainder of life and in the presence of a wide variety of physiological and pathological states.