By L. F. Bélanger, T. Semba, S. Tolnai, D. H. Copp, L. Krook, C. Gries (auth.), H. Fleisch, H. J. J. Blackwood, M. Owen (eds.)
The papers amassed during this quantity characterize the formal court cases of the 3rd eu Symposium on Calcified Tissues which was once held in Davos, Switzerland from eleventh to sixteenth April 1965 less than the sponsorship of the Laboratorium fur experi mentelle Chirurgie, Schweizerisches Forschungsinstitut Davos. This Symposium fol lowed the now tested culture of the former Symposia held in Oxford in 1963 and in Liege in 1964. Participation was once back strictly on a residential foundation. This yr the Schatz alp lodge supplied a scenic and secluded assembly position excessive on a mountain aspect overlooking Davos but just about the Forschungsinstitut during which the outlet consultation of the Symposium used to be held. The papers and communications released within the quantity are prepared so as of presentation and are grouped less than the 5 major subject matters chosen for dialogue by means of the Symposium, particularly, "Cell functionality within the formation, upkeep and destruc tion of osseous tissue", "Response of calcified tissues to mechanical factors", "Mecha nisms of mineralization and ailments regarding mineral deposition", "Hormones and bone" and "Fundamental constitution of dental not easy tissues". The programme consisted of a couple of assessment lectures given by means of invited audio system and of brief communications in terms of all of the above issues. No test was once made to list the dis cussions to the papers as, being a residential assembly, the extra precious and curiosity ing interchanges happened informally in small chat groups and never in the time agenda of the prearranged programme.
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Additional resources for Calcified Tissues 1965: Proceedings of the Third European Symposium on Calcified Tissues held at Davos (Switzerland), April 11th–16th, 1965
Collagen breakdown in soft and calcified connective tissues During growth, bone is under constant, rapid remodelling. This function is accomplished by the three types of bone cells, osteoblasts, osteocytes and osteoclasts. This remodelling seems to be required for some part of the homeostatic control of the calcium ion concentration in body fluid (McLEAN and ROWLAND, 1963) according to the dual mechanism of the control of calcium balance proposed by McLEAN and URIST (1961). As a part of this mechanism, bone cells are capable of tunelling compact bone to induce the formation of new haversian canals.
From these experiments it is obvious that the donor tissue has indeed the potency to form bone. However, this result does not prove that in grafts the donor tissue also produces bone. In order to get some information on this point donor cells were made distinguishable from host cells by labelling the donor tissue with 3H-thymidine prior to transplantation; in this way the fate of the donor cells during their presence in the host could be determined. Under these circumstances, we have to take into account the possibility that a donor cell could release its label when dying, and a host cell could then pick up the label.
Biochem. J. 65, 277 (1957). - , and ]. P. BENTLEY: On the nature of the extractable collagens. J. biophys. biochem. Cytol. 7, 37 (1960). JACKSON, S. : The structure of developing bone in the embryonic fowl. Proc. roy. Soc. B 146, 270 (1957). , R. E. ROWLAND, J. H. MARSHALL, and F. C. McLEAN: The effect of parathyroidectomy on haversian remodeling of bone. Endocrinology 63, 903 (1958). KRANE, S. , and M. J. GLIMCHER: Studies of the interaction of collagen and phosphate. II. Nucleotidase activity and binding of nucleotide phosphorus.