By Jochen Schacht, Richard R. Fay
The previous decade has introduced nice advances in our realizing of the mechanisms underlying auditory pathologies. This quantity offers fresh advancements in learn and their strength translation to the medical atmosphere. It brings jointly the fundamental and medical sciences very well in that whereas so much chapters are written through easy scientists, each one subject has a beautiful direct medical software or implication.
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Additional info for Auditory Trauma, Protection, and Repair (Springer Handbook of Auditory Research)
Astuto LM, Bork JM, Weston MD, Askew JW, Fields RR, Orten DJ, Ohliger SJ, Riazuddin S, Morell RJ, Khan S, Kremer H, van Hauwe P, Moller CG, Cremers CW, Ayuso C, Heckenlively JR, Rohrschneider K, Spandau U, Greenberg J, Ramesar R, Reardon W, Bitoun P, Millan J, Legge R, Friedman TB, Kimberling WJ (2002) CDH23 mutation and phenotype heterogeneity: a profile of 107 diverse families with Usher syndrome and nonsyndromic deafness. Am J Hum Genet 71:262–275. Avraham KB, Hasson T, Steel KP, Kingsley DM, Russell LB, Mooseker MS, Copeland NG, Jenkins NA (1995) The mouse Snell’s waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells.
Di Palma F, Holme RH, Bryda EC, Belyantseva IA, Pellegrino R, Kachar B, Steel KP, Noben-Trauth K (2001) Mutations in Cdh23, encoding a new type of cadherin, cause 40 E. B. Avraham stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nat Genet 27:103–107.
2002), whirlin (Mustapha et al. 2002; Mburu et al. 2003), DFNB33 (Medlej-Hashim et al. 2002), pendrin (Baldwin et al. 1995), DFNB17 (Greinwald et al. 1998) and most recently, TRIOBP (Shahin et al. 2006). An alternative approach was taken to search for mutations in 156 Palestinian deaf probands and their families (Walsh et al. 2006). Initially, connexin 26 mutations were found in 17% of the group. Thereafter, a hearingloss-targeted genome scan was performed on 10 families, using microsatelite markers flanking 36 loci associated with hearing loss.