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By Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)

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Original article The continuing challenge of Hodgkin's disease* Saul A. Rosenberg Stanford University School of Medicine, Stanford, California, USA Summary. Patients with Hodgkin's disease, treated at most major medical centers, enjoy a cure rate on the average of approximately 7 5 percent. An additional 5 or 10% will not die of Hodgkin's disease, because of the success of secondary treatments or because their deaths result from other related or unrelated causes. There are subgroups of patients who fare better or worse than this average, depending on prognostic factors such as age, stage, bulk, or site of disease and on the primary management program.

1__. I----J 14 4 8 10 12 0 16 2 6 YEARS Jan 1990 Fig. 2. Actuarial freedom from relapse and overall survival of 1344 consecutive patients from 1974-1989, according to histologic subtype of Hodgkin's disease. Jan 1990 Fig. 4. Actuarial freedom from relapse and overall survival of 1344 consecutive patients with Hodgkin's disease from 1974-1989 according to age at onset. ,_ 60 77% 80 72% 60 _________ _ 71% 56% 40 100 80 60 20 - -~ ~--,. 23 20 I I 12 14 16 YEARS Jan 1990 0 82% (38 pts) (34 pts) 60 SURVIVAL 0 2 3 4 5 6 7 8 9 YEARS Jan 1990 Fig.

Reassessment by bone marrow biopsy of the patient with previously documented bone marrow involvement now showed the marrow to be free of lymphoma. No consistent alteration in mean LV bone marrow T 2 was seen following treatment, although reduction or OL-----~--------------~--- Fig. 4. Pre- and post-treatment mean lumbar vertebral marrow T 1 of patients studied serially. ). n_•_____P_os_:_-tLre_a_tm_e_nt Fig. 5. Pre- and post-treatment percent T 1 variation of patients studied serially. ). normalisation of T 2 variation was seen in three of the four patients studied serially.

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